Recent studies have revealed the role of several cathepsins in promoting or inhibiting various cancers (e.g., lung (10), ovarian (11), thyroid (12), and colorectal (13)), including cathepsin B (CTSB) (14), cathepsin L (CTSL) (15), cathepsin G (CTSG) (16), and cathepsin S (CTSS) (17). This evidence concerns the gene CTSB and cancer.