Amrom et al (2014) published a case series describing four cases of patients with RE who went on to be diagnosed with comorbid autoimmune disorders (with systemic lupus erythematosus (SLE) (with elevated serum anti-double stranded deoxyribonuclease titre (anti-dsDNA)), Hashimoto thyroiditis (with positive serum antibodies to thyroglobulin and thyroperoxidase), Crohn’s disease, or ulcerative colitis found in each of the cases they reported). This evidence concerns the gene TPO and autoimmune disease.