RET and Hirschsprung disease: Mutations on chromosome 10q were among the first identified as causative in Hirschsprung disease [2], with certain mutations in the RET gene impacting SOX10 binding and correlating with a four-fold increase in incidence rates [3]. Diagnosis of Hirschsprung disease commonly occurs in neonates, often identified by the characteristic inability to pass meconium within the first days of life [4,5].