The lifetime risk of developing VTE is significantly higher in patients with protein S deficiency (such as in this case) (8.5 times higher), antithrombin deficiency (8.1 times higher), protein C deficiency (7.3 times higher), and Factor V Leiden mutation (2.2 times higher) compared to the general population. Here, F5 is linked to hereditary thrombophilia due to congenital protein S deficiency.