Supporting this notion, a large Chinese meta-analysis identified statistically significant differences (p < 0.01) in all MetS components (WC, BMI, TG, low-density lipoprotein-cholesterol (LDL-C), systolic blood pressure (SBP), diastolic blood pressure (DBP), fasting glucose, and insulin) except HDL-C (p = 0.72) between premenopausal and postmenopausal women [21]. This evidence concerns the gene INS and metabolic syndrome.