The ALS-ci group exhibited an older age at diagnosis (59.4 vs. 51.8 years, p < 0.001), lower educational level (7.1 vs. 10.3 years, p < 0.001), lower counts of leukocytes (5.68 vs. 6.47 × 10^9/L, p < 0.001), neutrophils (3.36 vs. 3.97 × 10^9/L, p = 0.001), monocytes (0.36 vs. 0.42 × 10^9/L, p = 0.001), a higher percentage of CD4+ T cells (41.09 vs. 38.75%, p = 0.03), higher levels of IgG (12.29 vs. 11.53 g/L, p = 0.01), IgM (1.44 vs. 1.18 g/L, p = 0.003), and a lower level of C3 (0.83 vs. 0.88 g/L, p = 0.01) compared to the ALS-nci group (Table 1). This evidence concerns the gene C3 and amyotrophic lateral sclerosis.