Regarding the role of CD4+ T cells in ALS, findings have also been controversial: while some studies have shown a negative correlation between the number of CD4+ T cells and ALSFRS-R scores (9, 10, 16), others have suggested a neuroprotective role for CD4+ T cells, particularly CD4 + CD25+ regulatory T cells, in ALS patients (17). The gene discussed is CD4; the disease is amyotrophic lateral sclerosis.