The top 10 hub genes were CCHCR1, CCR5, HLA-C, PMF1, LRRC37A, CASTOR3, IFNAR1, SLC25A44, DR1, and MACF1. The significant enriched biological pathways associated with LTL and COVID-19 susceptibility are detailed in Supplementary Table 10 and Supplementary Figure 2 A, including protein transmembrane transport, cellular aldehyde metabolic process, and mitotic G1 DNA damage checkpoint signaling. The gene discussed is CCHCR1; the disease is COVID-19.