TWAS analysis identified a series of important genes associated with LTL and COVID-19 risk, such as CCHCR1, HLA-C, PMF1, LRRC37A, CASTOR3, IFNAR1, SLC25A44, DR1, and MACF1. Coiled-coil alpha-helical rod protein 1 (CCHCR1) is a psoriasis susceptibility gene and plays a decisive role in controlling mRNA metabolism by interacting with mRNA uncapping protein 4 [79]. Here, DR1 is linked to psoriasis.