MPO (OR [95% CI] = 0.99 [0.98, 1.00], p = 2.87 ×10-2, proportion = 8.7%) and APOF (OR [95% CI] = 0.98 [0.96, 1.00], p = 4.59 ×10-2, proportion = 15.7%) partially mediated the causal effect between LTL and COVID-19 hospitalization. Here, MPO is linked to COVID-19.