C-C motif chemokine 19 (CCL19) and interleukin-6 (IL-6) were suggested to be protectively associated with the development of PPP (OR: 0.698,95% CI: 0.516–0.944, p = 0.020; OR: 0.656, 95%CI:0.437–0.985, p = 0.042). This evidence concerns the gene CCL19 and palmoplantar pustulosis.