Among them are “first-line” aPLs such as: antibodies against phosphatidylserine/prothrombin complex (aPS/PT IgG/IgA/IgM), aβ2GPI Domain I, IgA of aβ2GPI and aCL, which are highly specific for the identification of APS patients (9). Here, F2 is linked to autoimmune polyendocrinopathy.