CD40LG and autoimmune polyendocrinopathy: The latest classification criteria for the diagnosis of APS, include the following laboratory criteria: (i) persistent positive LAC, (ii) persistent aPLs, i.e. aCL and anti-β2GPI antibodies (IgG/IgM isotypes), moderate or high positive (IgM alone) (aCL and/or anti-β2GPI), moderate positive (IgG) (aCL and/or anti-β2GPI) with or without IgM, high positive (IgG) (aCL or anti-β2GPI) with or without IgM, high positive (IgG) (aCL and anti-β2GPI) with or without IgM (1).