MAPT and Alzheimer disease: While the specific reasons for the heightened vulnerability of entorhinal neurons, particularly those in layer II, to tau-related pathology and cell death in AD, are not fully known, factors such as elevated metabolic rates, neuronal plasticity, and a unique genetic profile related to tau homeostasis in this region are believed to play significant roles (Braak et al., 2006; Stranahan and Mattson, 2010; Fu et al., 2018).