HBE1 and chronic hepatitis B virus infection: The results of this study are in accordance with the research of Widita et al. in 2010, which stated that out of 105 serum samples of chronic hepatitis B patients as research subjects, there were more HBeAg negative samples, as many as 80 samples, namely 76.19% (consisting of negative HBeAg and anti-HBe positive, which was more dominant (82.5%) compared to negative HBeAg and anti-HBe negative) [19].