MGMT and glioblastoma: Moreover, we evaluated the genetical characteristics of GBM, including MGMT promoter methylation status and EGFR amplifications. The most prevalent location was the frontal lobe, with 46 cases (31.9%), shortly followed by multilobular GBM, with 38 cases (26.3%), both accounting together for 84 (58.3%) out of the total 144 cases (Figure 7).