These soluble NKG2D ligands (sMICA and sMICB) can bind to NKG2D, lead to downmodulation of NKG2D and subsequent functional impairment of NKG2D‐dependent activation, and finally facilitate tumor progression206, 207, 208, 209, 210, 211 (Figure 4B). Here, KLRK1 is linked to neoplasm.