This overexpression is influenced by epigenetic mechanisms (DNA methylation and histone modifications),176, 177 and tumor microenvironmental factors,178, 179, 180 particularly hypoxia, which stabilizes the hypoxia‐inducible factor 1 (HIF‐1α) and other factors, leading to increased HLA‐G expression.181. This evidence concerns the gene HLA-G and neoplasm.