The most well studied CIC targets include the PEA3 family of transcription factors, namely ETV1, ETV4, and ETV5. In the context of cancer, genetic loss or functional suppression of CIC derepresses ETV1, ETV4, and/or ETV5 in multiple subsets of human cancer such as lung, gastric, breast, and colorectal cancer, resulting in enhanced tumor proliferation, self-renewal, and invasion/metastasis (Okimoto et al., 2017; Lee et al., 2020; Yoe et al., 2020). The gene discussed is ETV4; the disease is colorectal cancer.