Interestingly, a significant percentage of CIC::NUTM1 tumors localized to the CNS, with over 70% confined to the spine (cervical and thoracic levels) and brain (temporal and occipital areas of meninges, parenchyma, and sarcoma, trigone of the lateral ventricle, interventricular foramen, parietal lobes) with others infrequently observed in the lung and kidney soft tissue (Sturm et al., 2016; Mangray et al., 2018; Schaefer et al., 2018; Watson et al., 2018; Le Loarer et al., 2019; Biederman et al., 2022; Yang et al., 2022; Ma et al., 2023; Sievers et al., 2023) (Figure 2). Here, NUTM1 is linked to sarcoma.