Preclinical studies identified CIC::DUX4 to molecularly depend on cell cycle mediators CCNE1 and WEE1 (Okimoto et al., 2019; Ponce et al., 2022) with CCNE1 being established as a direct transcriptional target of CIC::DUX4 that drives tumor growth and survival through an acquired dependence on CCNE/CDK2 complex. Here, DUX4 is linked to neoplasm.