VEGFA, PDGFRB, ANGPTL4 and ENG have been shown to play major roles in angiogenesis and vascular homeostasis, not only in physiological regeneration but also in most pathological angiogenic processes such as cancer (Raica and Cimpean, 2010; Nassiri et al., 2011; Shibuya, 2011; Uccelli et al., 2019; Fernandez-Hernando and Suarez, 2020). The gene discussed is ENG; the disease is cancer.