FOXO1 and gastric cancer: We found that the regulons mediated by FOXO1 were specific in PMCs and the activity of FOXO1-mediated regulons was suppressed in PMCs of the H. pylori-infected group compared with the uninfected group, consistent with the previous finding that the FOXO1 plays a role in inhibiting the proliferation and invasion of GC cells (Fig. 1G, H; Fig. S8A, B; Supplementary materials and methods).