CD4 and neoplasm: Besides, the TIP score was positively correlated with multiple immune-related indicators including CD8/CD4 T cells, the expression of PD-1/CTLA-4, immune/stromal/estimate score, and cytotoxic T lymphocyte (CTL)/cytolytic activity (CYT)/tumor immune escape/tumor inflammation signature (TIS) score, while negatively correlated with tumor purity (Fig. S1B–D).