Serial doppler ultrasound imaging analysis showed that the suprarenal AA expansion was significantly inhibited in the AB4 treatment group compared with the model group (Figures 1D, E). Histologically, we performed H&E, Masson-Trichrome, and Elastin and Van Gieson (EVG) staining on the crosssections of AAA samples and observed that intraluminal thrombus was formed, aortic adventitial thickened and matrix remodeled, collagen fibers were deposited, and elastic fibers were broken and degenerated, after 4 weeks of Ang II infusion. The gene discussed is AGT; the disease is triple-A syndrome.