In SA region, the expression of IL-6, gp130, and JAK2 was lower in tumor tissues in IL-6+gp130+, IL-6+JAK2+, and IL-6+gp130+JAK2+ cells (P < 0.05); and the expression of IL-6R, CRP was also lower in tumor tissues in IL-6R+CRP+, IL-6R+STAT3+, and IL-6R+CRP+STAT3+cells (P < 0.05) (Supplementary Figure 3). Here, CRP is linked to neoplasm.