IL6R and cholangiocarcinoma: Although none of the gene expressions were associated with OS and DFS, our study revealed an inverse association between IL-6, IL-6R, CRP, gp130, and JAK2 with vascular invasion, leading to a poor prognosis in patients with CCA (OS: aHR = 1.885, 95% CI = 1.118 - 3.179, P = 0.017; DFS: aHR = 2.172, 95% CI = 1.252 - 3.768, P = 0.006).