CTNNB1 and obesity due to melanocortin 4 receptor deficiency: Table 5 lists the keywords, centrality, and first appearance for the top 20 cooccurrences. Intermediary centrality analysis reveals the mutation or transformation of research hotspots. CiteSpace was used, resulting in 294 keywords. Larger nodes correspond to more frequent cooccurrences. Purple outer ring node is an important keyword: expression, amino acid sequence, activation, beta-catenin, protein, obesity (Figure 8).