Table 5 lists the keywords, centrality, and first appearance for the top 20 cooccurrences. Intermediary centrality analysis reveals the mutation or transformation of research hotspots. CiteSpace was used, resulting in 294 keywords. Larger nodes correspond to more frequent cooccurrences. Purple outer ring node is an important keyword: expression, amino acid sequence, activation, beta-catenin, protein, obesity (Figure 8). Here, CTNNB1 is linked to Obesity.