TLR4 and necrotizing enterocolitis: In looking at the interaction of long non-coding RNAs (lncRNA), differentially expressed lncRNAs were identified in a rat NEC model (upregulated MSTRG.42950 and MSTRG.104993, and downregulated MSTRG.61378 and MSTRG.81980) which bound target miRNAs (miR181a-5p, miR-124-3p, miR-194- 5p, and miR-362-3p) to modulate TLR4 signaling in NEC inflammation (49).