In addition, this tumor frequently displays the robust expression of one or more stem cell markers, such as SOX2, CD34, and SALL4, which can facilitate the differential diagnosis of SMARCA4-deficient non-small cell lung cancer (NSCLC) (SMARCA4-dNSCLC), typically negative for these markers (13, 14). The gene discussed is SOX2; the disease is non-small cell lung carcinoma.