IGHE and Increased total eosinophil count: Bark and leaf extracts did not alter TNF-α production but inhibited the transcription of NF-kB. The extracts decreased the total number of inflammatory cells in bronchoalveolar lavage fluid (BAL) samples. Bark and leaf extracts decreased eosinophilia in BAL, but bark extract was more effective. The 200 mg/kg dose of bark extract killed all animals. The extracts did not alter TNF-α. The extracts reduced eosinophils and increased neutrophils. Macrophages and lymphocytes were not affected. The extracts increased TGF-β and did not alter IgE levels