CD44 and neoplasm: UT increased the CD4/CD8a ratio (1,000 mg/kg) and the CD4+CD44+/CD8a+CD44+ ratio (50 and 500 mg/kg). It increased the proportion of myeloid dendritic cells. It induced a pro-inflammatory Th1 profile and reduced the Th17 response. It increased TNF-α and reduced IL-17A and IL-2, whereas IL-4 was not altered. Within the tumor: there were no differences in IL-12p70 and MCP-1