CD4 and hypertensive disorder: Treatment with AC-11 decreased AngII-induced hypertension. AC-11 decreased the population of CD8+T cells, the ratio of CD8/CD4, and plasma interleukin-6 levels in pregnant and non-pregnant mice. AC-11 decreased plasma levels of sFlt-1 and sEng in pregnant mice, and this effect was confirmed in an in vitro assay