Subsequently, KEGG pathway revealed that RBFOX2 expression was correlated with neurodegeneration-multiple diseases, mismatch repair, DNA replication, DNA replication, homologous recombination, fanconi anemia pathway, spinocerebellar ataxia, breast cancer and pathogenic Escherichia coli infection, as well as associated with spliceosome (Supplementary Figure S7E,F). This evidence concerns the gene RBFOX2 and escherichia coli infection.