Despite previous study and our results found that the downregulation of RBFOX2 mRNA in colorectal cancer tissue compared to normal tissue in the colon cancer TCGA data (Danan-Gotthold et al., 2015), RBFOX2 protein expression was found to be upregulated in colorectal cancer (Choi et al., 2019). Here, RBFOX2 is linked to colonic neoplasm.