Cel is thought to improve skeletal muscle and bone function through upregulation of the AMPK signaling pathway (Abu et al., 2020; Li et al., 2020), and it also ameliorates angiotensin II-mediated vascular smooth muscle cell senescence (Xu et al., 2017) and osteoarthritis (Feng et al., 2020) through the induction of autophagy. The gene discussed is AGT; the disease is osteoarthritis.