However, significant elevated Caspase 1 cleavage was detected in PBMCs of SLE patients (Figure 1A), suggesting an enhancement in Caspase 1‐mediated pyroptosis, which was independent of Nlrp1, Aim2, Nlrp3, and Nlrc4 inflammasomes. This evidence concerns the gene AIM2 and systemic lupus erythematosus.