However, significant elevated Caspase 1 cleavage was detected in PBMCs of SLE patients (Figure 1A), suggesting an enhancement in Caspase 1‐mediated pyroptosis, which was independent of Nlrp1, Aim2, Nlrp3, and Nlrc4 inflammasomes. The gene discussed is NLRC4; the disease is systemic lupus erythematosus.