NFKB1 and systemic lupus erythematosus: Moreover, the cleavage of GSDMD and Caspase 11 induced by lupus serum was attenuated by the Caspase 11 inhibitor wedelolactone (WDL), a natural compound that suppresses Caspase 11 expression by inhibiting NF‐κB‐mediated transcription,20 indicating that the pyroptosis‐inducing effect of lupus serum on macrophages was Caspase 11‐dependent.