BDNF and major depressive disorder: Specifically, DNA methylation (5mC) and hydroxymethylation (5hmC) have been implicated in the development of depression.[5] These epigenetic modifications contribute to depression by regulating the transcriptional activity of genes associated with the condition, such as brain‐derived neurotrophic factor (BDNF) and Glutathione Reductase (GR).[6, 7] The ten‐eleven translocation (Tet) family of enzymes, including Tet1, Tet2, and Tet3play a crucial role in depression by facilitating the conversion of 5mC to 5hmC in DNA and RNA.