PIK3C3 and Alzheimer disease: The core subunits of the VPS34 complex, Beclin‐1, and PI3P were downregulated in AD patients’ brains.[60, 61] Herein, we did not detect alterations in autophagy levels in the PFC of AD mouse models, potentially due to regional specificity within the brain.[62] ECM remodeling upregulated the expression of Rab7 and Lamp1, and increased the colocalization of Aβ with Rab7 and Lamp1 in astrocytes.