DEPP1 and ischemia: A recent study showed DEPP1 inhibition suppressed MPTP opening in the setting of mitochondrial Ca2+ overload, a key step in cardiomyocyte death in the setting of ischemia, suggesting DEPP1 may play a role in mitochondrial Ca2+ homeostasis.78,79 In line with this, we find DEPP1 is sufficient to induce MPTP opening (Figure 5F).