TFEB and heart failure: Conversely, Beclin 1 overexpression increases autophagy and pathological cardiac remodeling.59 Similarly, activation of Tfeb (transcription factor EB), a master regulator of lysosomal biogenesis and autophagy, causes heart failure in mice in the setting of pressure overload.60 It will be important to confirm experimentally whether increasing autophagy of mitochondrial and peroxisomes is sufficient to induce cardiac dysfunction.