These cells were then induced to become cardiomyocytes (hiPS-CMs) and treated with doxycycline (Figure S18A).41 We previously showed that HIF2α-dPA is sufficient to cause cardiomyopathy in vivo.1 HIF2α-dPA increased hIPS-CM DEPP1 abundance and decreased hIPS-CM survival (Figure S18A and S18B). This evidence concerns the gene ISYNA1 and cardiomyopathy.