Similarly, autophagy-mediated mitochondrial clearance controls beige adipocyte maintenance, and autophagy inhibition prevents beige adipocyte loss and protects against diet-induced insulin resistance in mice.77 Because Depp1 deficiency induces white adipocyte browning (“beiging”) and protects against diet-induced insulin resistance in mice, it would be of interest to understand DEPP1 and its role in adipocyte autophagy and adaptive thermogenesis.28 The gene discussed is DEPP1; the disease is Insulin resistance.