Hypoxia induces HIF, and HIF activation in mice is sufficient to promote many features of ischemic cardiomyopathy, including autophagy induction and lipid accumulation.1–3,29 To ask whether DEPP1 is sufficient to induce autophagy, we stably expressed DEPP1, DEPP1 ΔTsnare, or empty vector in cardiomyocytes (Figure 5A). This evidence concerns the gene DEPP1 and ischemic cardiomyopathy.