Although it is known that c-Src expression is increased in human cancers and c-Src is a well-known promotor of tumour angiogenesis (Eliceiri et al., 1999; Simatou et al., 2020), the specific mechanisms by which changes in ECM stiffness activate endothelial c-Src to induce MMP secretion remain unknown. Here, SRC is linked to neoplasm.