CXCR3 expression remained markedly lower in the CX3CR1+ subset than in the CX3CR1− subset of Pmel-1 T cells in the spleen (Fig. 2H), suggesting that peripheral CX3CR1+ Pmel-1 T cells have a decreased capacity to migrate to the tumor microenvironment via the CXCR3-CXCL9/CXCL10 axis (31). Here, CXCL9 is linked to neoplasm.