TP53 and cancer: Furthermore, Li-fraumeni syndrome (LFS) is an extremely rare autosomal-dominant hereditary disorder characterized by a germline mutation in the tumour-suppression gene TP53, with an estimated 50-fold risk over the general population of developing several types of cancer.34 Although endometrial and ovarian cancers have been found to occur excessively in some families who have met criteria for LFS, their link to the syndrome is not definitely established.