This TET2‐mediated post‐transcriptional regulation is central to the TSPAN13/CXCR4 axis, highlighting the significance of the TET2/m5C interplay in AML pathogenesis and LSC homing/self‐renewal and suggesting potential therapeutic avenues for TET2‐deficient AML.26 Here, CXCR4 is linked to acute myeloid leukemia.