In addition, Cap methyltransferase 1 (CMTR1) and CMTR2 were both identified as mRNA 2′‐O‐methyltransferases,96 and Hua enhancer 1 (Hen1), a small RNA 2′‐O‐methyltransferase, was found to be dysregulated in different cancer cells.97 This evidence concerns the gene CMTR1 and cancer.