Chen et al. [193] proposed a protein hybridization method for combining HSA and Hb to develop a bioinspired hybrid protein oxygen nanocarrier (C@HPOC) loaded with photosensitizer e6 (Ce6), which overcomes tumor hypoxia via co-delivery of tumor-targeted O2 and PS and improves PDT efficacy by generating a large amount of 1O2. Here, ALB is linked to neoplasm.