In total, 6 (85.7%) cases were diagnosed as severe haemophilia according to baseline FVIII level, 4 (57.1%) cases had a high titer inhibitor development after surgery, 6 (85.7%) cases had history of intensive FVIII exposure for previous surgery, 2 (28.6%) cases underwent surgery for haemophilia pseudotumor (Table 3). The gene discussed is F8; the disease is hemophilia.