After that, we compared the differences in the expression levels of GAMT, ORC1, CNGB3, and SERPINE1 in unpaired and paired gastric cancer tissues and normal gastric tissues from the TCGA database, and the results showed that the expression of the GAMT gene was significantly down-regulated in the gastric cancer tissues, and that the expression of ORC1, CNGB3, and SERPINE1 was significantly up-regulated in the tumor tissues with significantly up-regulated expression (Fig. 2A−B). This evidence concerns the gene SERPINE1 and neoplasm.