Wu et al [36] also speculated that high expression of NTR1 is associated with neuroendocrine differentiation of PCa, which makes NTR1 a potential target for neuroendocrine PCa, and PSMA imaging may have false negative in NEPC patients, but targeted NTR1 imaging may make up for the deficiency of PSMA, but their research was limited to cells and animals study. This evidence concerns the gene NTSR1 and posterior cortical atrophy.