ZNF281 highly expressed in BRCA (Breast invasive carcinoma), COAD (Colon adenocarcinoma), CHOL (Cholangiocarcinoma), ESCA (Esophageal carcinoma), HNSC (head and neck squamous cell carcinoma), LUAD (lung adenocarcinoma) and STAD (Stomach adenocarcinoma) (Fig. 2A). This evidence concerns the gene ZNF281 and lung adenocarcinoma.