ZNF281 highly expressed in BRCA (Breast invasive carcinoma), COAD (Colon adenocarcinoma), CHOL (Cholangiocarcinoma), ESCA (Esophageal carcinoma), HNSC (head and neck squamous cell carcinoma), LUAD (lung adenocarcinoma) and STAD (Stomach adenocarcinoma) (Fig. 2A). The gene discussed is ZNF281; the disease is cholangiocarcinoma.