PIK3CA and Venous malformation: Specifically, PIK3CA-related venous malformations showed a mean reduction of 33.4% (SD, ± 22.1) from the baseline at 6 months, while TEK-related venous malformations demonstrated a mean reduction of 27.8% (SD, ±18.9) (Tables 1 and 2, Fig. 5f and Supplementary Fig. 16).