AKT1 and vascular malformation: Upon inducing Cre induction, we observed that AKT1 deletion in capillaries and veins led to a moderate extension of lifespan (median survival of 80 days) and only delayed the occurrence of vascular malformations (Fig. 2a and Supplementary Fig. 8a) as MRI performed at 6 weeks still revealed diffused venous malformations (Fig. 2b and Supplementary Fig. 8b).