NFKB1 and chronic obstructive pulmonary disease: Notably, the decreased expression of type-I IFNs has been previously reported in COPD contexts, the suppressed type-I IFNs in COPD might compromise the antiviral defence ability, thus contributing to persistent airway inflammation and even acute exacerbations.56,57 These findings emphasised the key role of NETs-DNA and the associated NF-κB signalling, but not type-I IFNs response, in sustained airway inflammation in COPD.