TOMM20 and chronic obstructive pulmonary disease: Additionally, 5% CSE exposure triggered co-localisation of oxidative DNA damage marker 8-OHdZG (8-hydroxy-2’-deoxyguanosine) with mitochondrial membrane protein TOMM20 (outer mitochondrial membrane complex subunit 20) on the hPBNs (Fig. 2j) and enhanced 8-OHdZG staining in CSE-NETs derived from both healthy participants and patients with COPD (Fig. 2k and supplementary Fig. S4h).