Notably, adeno-associated virus (AAV) delivery of an shRNA to arylsulfatase B (N-acetylgalactosamine-4-sulfatase, ARSB), to increase CS 4-0 levels in the LH, reduced anxiety and prevented the expression of preference for cocaine in a novelty-induced conditioned place preference test during cocaine withdrawal. The gene discussed is ARSB; the disease is Anxiety.