In the adjusted analysis, increasing age, unemployment (adjusted HR 1·37 [95% CI 1·04–1·80]), excessive alcohol use (1·47 [1·14–1·89]), history of smoking (1·34 [1·05–1·71]), HIV-positive status (1·53 [1·16–2·01]), presence of bilateral pulmonary cavities on x-ray (1·68 [1·29–2·19]), elevated baseline aspartate aminotransferase or alanine aminotransferase (1·40 [1·13–1·73]), and baseline anaemia (1·46 [1·15–1·86]) were all positively associated with unsuccessful study outcomes. The gene discussed is GPT; the disease is anemia (phenotype).