AGT and hypertensive disorder: In addition to the heart and aorta, Cmpd17b reduced kidney damage as reflected by lower fibrosis and improved kidney weight in vehicle-treated hypertensive mice, consistent with previous reports that an excess of Ang II caused renal impairment and kidney damage.37 We have demonstrated the preventive effects of Cmpd17b against Ang II-induced hypertension and end-organ damage as proof of concept.