Ang II induces hypertension by acting on AT1 receptors to cause vasoconstriction, sympathetic nerve stimulation, increased aldosterone biosynthesis, and increased sodium retention by the kidney.25 Administration of a single dose of Cmpd17b promptly lowered MAP acutely on Day 2, and the MAP lowering effect was potentiated on Day 28. Here, AGT is linked to hypertensive disorder.