The acute vasodepressor effect of Cmpd17b in vivo is consistent with relaxation previously reported in isolated aorta and mesenteric arteries.10 The potentiated vasodilator response to Cmpd17b on Day 28 compared to Day 2 suggests a vascular amplifying effect with chronic Ang II infusion, which may be due to more vascular remodelling and narrower arterial lumen on Day 28 compared to Day 2.26 Chronic Cmpd17b administration attenuated the development of hypertension in Ang II-infused mice. This evidence concerns the gene AGT and hypertensive disorder.