AGT and hypertensive disorder: Cardiovascular hypertrophy and fibrosis are characteristic structural changes that develop during hypertension.27 Previous studies demonstrated that Ang II-dependent hypertension is associated with myocardial enlargement and collagen accumulation in the LV and aorta.28–30 In our study, fibrosis (demonstrated by collagen deposition) was elevated in the LV and abdominal aorta of hypertensive mice.