AGT and cardiac hypertrophy: We observed that LV weight was greater in hypertensive mice than their normotensive counterparts, indicating LV hypertrophy results from chronic Ang II infusion, consistent with previous report.30 LV cardiomyocyte hypertrophy, specifically cardiomyocyte width (an early sign of enlarged cardiomyocytes), in hypertensive mice was also evident in response to Ang II infusion.