CASP1 and rheumatoid arthritis: NLRP3 expression, regulated by NF-κB binding to the NLRP3 promoter [44], and the NLRP3 inflammasome, implicated in RA development, play a pivotal role in caspase-1 activation, which mediates the maturation and secretion of IL-1, a pro-inflammatory cytokine [45, 46].