Additionally, KMU-11342 exhibited a significant inhibitory effect on the LPS-stimulated up-regulation of chemokine mRNA levels, including CXCL10, CCL2/MCP-1, CCL3/MCP-1α, and CCL4/MCP-1β, in Human RA-FLS (Fig. 3C-F). This evidence concerns the gene CCL4 and rheumatoid arthritis.