In summary, this study explored the anti-rheumatic properties of KMU-11342 by inhibiting the TLR4/NF-κB/NLRP3 inflammasome signaling in LPS-stimulated RA-FLS and THP-1 cells, and by attenuating osteoclast differentiation. The gene discussed is NFKB1; the disease is rheumatoid arthritis.