We and others have previously found that lactate accumulates not only during KSHV latent infection [22, 23], but also in the medium of iSLK-KSHV cells after doxycycline induction (Fig. 2A), indicating that lactate-driven lysine lactylation may be involved in NAT10-mediated viral reactivation. The gene discussed is NAT10; the disease is disease arising from reactivation of latent virus.