Also notable is the patient’s established diagnosis of Lynch syndrome, a well-described, autosomal dominant hereditary cancer syndrome that is caused by a germline mutation in DNA mismatch repair (MMR) such as MLH1, MLH2, MSH6, and PMS2. These genes, when functional, help to maintain genomic integrity by correcting small base pair substitution and insertion-deletion errors. This evidence concerns the gene MSH6 and Lynch syndrome.