BAP1 and cancer: Furthermore, in compound conditional knockout (CKO) mice with simultaneous inactivation of Bap1 and Nf2, the incidence of HCC (hepatocellular carcinoma) and ICC (intrahepatic cholangiocarcinoma) was greater (28 of 42, 66.7%), while the tumorigenesis of MM occurred earlier than that of other types of tumors in these mice, indicating the potential role of cooccurring mutations in tumorigenesis and the development of cancer types103.