We propose three main approaches for determining the mechanism by which the loss of NF2 affects the regulation of immune cells (Fig. 6): (1) NF2 impacts tumor immunity by regulating the expression of specific molecules and signalling pathways in tumors, and (2) Merlin mutants (NF2m, with missense mutations in the N-terminal FERM domain) can directly influence tumor immunity. Here, NF2 is linked to neoplasm.