As expected, although the weight and blood glucose of Ehhadh KO mice were slightly lower than those of WT mice under diabetic conditions, they still displayed more severe tubulointerstitial injury, indicating the importance of EHHADH in tubulointerstitial injury under hyperglycemia, which also is in agreement with previous findings that PEX11a deficiency aggravated renal interstitial lesions in mice [39]. Here, PEX11A is linked to Hyperglycemia.