Compared to those in CD4+ T cells in the control group, MDV altered the ubiquitylome associated with signal transduction and the immune system, cancer, and infectious disease pathways in CD4+ T lymphoma cells; this result may facilitate future studies on the mechanisms underlying MDV-induced immunosuppression and tumorigenesis in T cells in relation to the regulation of ubiquitination97. The gene discussed is CD4; the disease is cancer.