As the level of TRPV6 in metastatic PCa cell line PC3Mtrpv6+/+ was relatively low (Fig. 2A), we used our PC3Mtrpv6-/-+pTRPV6 cell line which has an increased amount of TRPV6 (Fig. 2B), to record the treatment kinetics and determine whether the level of TRPV6 expression correlated with mAb82 efficiency. Here, TRPV6 is linked to posterior cortical atrophy.